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Research & Publications

For a complete list of publications, please visit PubMed.gov

Please click on the title to access PDF versions of our publications.

Targeting S100A9-ALDH1A1-retinoic acid signaling to suppress brain relapse in EGFR-mutant lung cancer.

Biswas AK, Han S, Tai Y, Ma W, Coker C, Quinn SA, Shakri AR, Zhong TJ, Scholze H, Lagos GG, Mela A, Manova-Todorova K, de Stanchina E, Ferrando AA, Mendelsohn C, Canoll P, Yu HA, Paik PK, Saqi A, Shu CA, Kris MG, Massague J, Acharyya S. Cancer Discov. 2022 Jan 25:candisc.0910.2021.

PMID: 35078784. doi: 10.1158/2159-8290.CD-21-0910. Epub ahead of print.

 

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Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas.

Paik PK, Luo J, Ai N, Kim R, Ahn L, Biswas A, Coker C, Ma W, Wong P, Buonocore DJ, Lai WV, Chaft JE, Acharyya S, Massagué J, Kris MG. Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas. Nat Commun. 2022 Oct 15;13(1):6095. doi: 10.1038/s41467-022-33719-6. PMID: 36241629; PMCID: PMC9568581.

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Understanding cachexia in the context of metastatic progression.

Biswas AK, Acharyya S Nat Rev Cancer. 2020. PMID: 32235902, DOI: 10.1038/s41568-020-0251-4

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Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.

Wang G, Biswas AK, Ma W, Kandpal M, Coker C, Grandgenett PM, Hollingsworth MA, Jain R, Tanji K, LÏŒpez-Pintado S, Borczuk A, Hebert D, Jenkitkasemwong S, Hojyo S, Davuluri RV, Knutson MD, Fukada T, Acharyya S Nat Med. 2018. PMID: 29875463, DOI: 10.1038/s41591-018-0054-2

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A CXCL1 paracrine network links cancer chemoresistance and metastasis.

Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J Cell. 2012. PMID: 22770218, DOI: 10.1016/j.cell.2012.04.042

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Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.

Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagué J Nat Med. 2011. PMID: 21706029, DOI: 10.1038/nm.2379

 

Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.

Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC J Clin Invest. 2007. PMID: 17380205, DOI: 10.1172/JCI30556

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Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.

Acharyya S, Butchbach ME, Sahenk Z, Wang H, Saji M, Carathers M, Ringel MD, Skipworth RJ, Fearon KC, Hollingsworth MA, Muscarella P, Burghes AH, Rafael-Fortney JA, Guttridge DC Cancer Cell. 2005. PMID: 16286249, DOI: 10.1016/j.ccr.2005.10.004

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Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.

Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, Guttridge DC

J Clin Invest. 2004. PMID: 15286803, DOI: 10.1172/JCI20174

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